CLOVE LEAF OIL
clove oil
CAS: 8000-34-8
Molecular Formula: C7H12ClN3O2
CLOVE LEAF OIL - Names and Identifiers
CLOVE LEAF OIL - Physico-chemical Properties
| Molecular Formula | C7H12ClN3O2 |
| Molar Mass | 205.64208 |
| Density | 1.05g/mLat 25°C |
| Melting Point | FCC |
| Boling Point | 251°C(lit.) |
| Flash Point | >230°F |
| Water Solubility | Insoluble in water |
| Solubility | Insoluble in water |
| Appearance | Pale yellow liquid |
| Color | Yellow |
| Merck | 13,2443 |
| Storage Condition | 2-8℃ |
| Stability | Stable. Probably combustible. |
| Sensitive | Sensitive to light |
| Refractive Index | n20/D 1.532(lit.) |
| MDL | MFCD00130815 |
| Physical and Chemical Properties | The flower bud of the evergreen tree clove (Syzygium aromaticum, or Eugenia caryophyllata). The harvest time was about 15mm long, and the color began to turn red, and the one without Bud was preferred. After drying, it was iron-like, black-brown, with a blunt quadrangular almost cylindrical receptacle, with narrow lower end, with four upper lobes dividing into triangular flexible Leatheroid calyx. About 10 to 15 buds per gram of dried flowers. There is a strong clove aroma, with a burning spicy taste. Can increase appetite. For meat, baked products, potato chips, mayonnaise, salad seasoning and other anti-oxidative, anti-mildew effect. Native to the Maluku Islands in Indonesia, China's Guangdong, Guangxi and Tanzania, Malaysia, Sri Lanka, India and South Asia and the Indian islands countries. |
| Use | Medicine for antiseptic and oral Disinfection, the industry is mainly used for the preparation of toothpaste and soap flavor or used as a raw material for the synthesis of vanillin |
CLOVE LEAF OIL - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R21/22 - Harmful in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | GF6900000 |
CLOVE LEAF OIL - Reference
| Reference Show more | 1. He Zuyu, Li puwang, Yang Zi-Ming, Wang Chao, Liu Yunhao, Yao Jinsheng, Song Shuhui, Zhou Chao. Preparation of amphiphilic chitosan drug-loaded nano-micelles and their antibacterial activity against Botrytis cinerea [J]. Functional Materials, 2020,51(11):11182-11188. 2. He, Ruipeng, et al. "Effective of eugenol as an anestetic for adult spotted sea bass (Lateolabrax maculatus)." Aquaculture 523 (2020): 735180.https://doi.org/10.1016/j.aquaculture.2020.735180 |
CLOVE LEAF OIL - Nature
Open Data Verified Data
is a colorless to light yellow oily liquid with clove aroma and special spicy aroma. Long-term placed in the air can be oxidized and dark color, soluble in ether, acetone, ethyl acetate and other organic solvents, soluble in ethanol, insoluble in water.
Last Update：2024-01-02 23:10:35
CLOVE LEAF OIL - Preparation Method
Open Data Verified Data
obtained by steam distillation of unflowering flower buds of clove tree, the yield is close to 20%.
Last Update：2022-01-01 11:15:34
CLOVE LEAF OIL - Standard
Authoritative Data Verified Data
This product is a volatile oil extracted by steam distillation from dried flower buds of the myrtol plant clove (Em-Holum ema ca-Phylla Atat h u n B.). The content of Lu-syringene (C15H 24) should be 5. 0% ~ 1 4 .0%, containing eugenol (C1QH 120 2) should be 75.0% ~ 8.0%, containing eugenol acetate (C12H 140 3) should be 4 .0% to 15%, 0%.
Last Update：2024-01-02 23:10:35
CLOVE LEAF OIL - Trait
Authoritative Data Verified Data
- This product is a yellowish to yellow clear liquid; There is the aroma of clove, spicy taste, and there is a feeling of numbness and tongue; In the air, it is easy to deteriorate.
- This product is highly soluble in ethanol, ethyl ether, glacial acetic acid or toluene, and is almost insoluble in water.
relative density
The relative density of this product (General 0601) is 1.038~1.060.
optical rotation
take this product, determination according to law (General 0621), optical rotation should be 0 ° to a 2.0 °.
refractive index
The refractive index of this product (General 0622) is 1. 528~537.
Last Update：2022-01-01 11:19:58
CLOVE LEAF OIL - Application
Open Data Verified Data
It can be used as the raw material for the preparation of food flavor, and it is also the main raw material for the extraction of eugenol.
Last Update：2025-08-19 16:24:40
CLOVE LEAF OIL - Differential diagnosis
Authoritative Data Verified Data
- take about 80 m g of this product, add 2M l of toluene to dissolve, as a test solution. In addition, an appropriate amount of a control substance of eugenol and eugenol acetate was taken, and a mixed solution containing 25mg each in 1 μl of toluene was prepared as a control solution. According to the thin layer chromatography (General 0502) test, draw 2u1 of each of the above two solutions, respectively point on the same silica gel GF254 thin layer plate, with toluene as the developing agent, expand and take out, after placing for 5 minutes, perform the second unfolding, take it out, dry it, and examine it under a UV lamp (254nm), the chromatogram of the reference solution should show two clearly separated spots (the spots are eugenol and eugenol acetate from top to bottom), the position and color of the dominant spots in the chromatogram of the test solution should be the same as the spots of eugenol and eugenol acetate in the control solution. Then spray with anisaldehyde solution (anisaldehyde 0. 5ml, add glacial acetic acid 10ml to dissolve, add methanol 85ml and sulfuric acid 5ml, shake, then get. In the new system), heated at 105°C for 5 to 10 minutes, the position and color of eugenol and eugenol acetate in the chromatogram of the test solution should be the same as those of eugenol and eugenol acetate in the reference solution, below the solvent front and the eugenol acetate spot, one red spot should be shown, the solvent front spot being B- syringene.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be the same as that of the control solution/3-syringene peak, the retention times of eugenol and eugenol acetate peaks were consistent.
above (1), (2) two items can be done one.
Last Update：2022-01-01 11:19:59
CLOVE LEAF OIL - Exam
Authoritative Data Verified Data
solution clarity
take this product lm l, add 70% ethanol 2M l to dissolve, check according to law (General Rule 0 9 0 2 ) , the solution should be clear.
water-soluble phenols
take this product l t n l, heat water 20 m l, shake, cool, filter with water wet filter paper, add 1 drop of ferric chloride test solution to the filtrate, blue or purple color shall not be exhibited except for the gray-green color which is easy to disappear.
fatty oils and resinified essential oils
take this product 1 drops on the filter paper, 24 hours of oil droplets should be completely volatile, not to leave translucent or oily spots.
Heavy metals
take this product l .O g, determination according to law (General 0821 second method), containing heavy metals shall not exceed 10 parts per million.
Last Update：2022-01-01 11:20:00
CLOVE LEAF OIL - Content determination
Authoritative Data Verified Data
measured by gas chromatography (General 0521).
chromatographic conditions and system suitability test
A capillary column with polyethylene glycol as a stationary liquid (or similar polarity), the initial column temperature is 8 0°C, the temperature is maintained for 1 min, and then the temperature is raised to 1 8 0°C at a rate of 3°C per minute, this was maintained for 2 minutes at an inlet temperature of 250°C and a detector temperature of 250°C. Take the control solution 1 that is 1, inject human gas chromatography, the peak order of each component is eugenene, eugenol, eugenol acetate.
preparation of internal standard solution
take an appropriate amount of ethyl salicylate, add n-hexane to dissolve and dilute to prepare a solution containing about 9mg per 1 ml.
assay
take about O . lg of this product, weigh it accurately, put it in a 10ml measuring flask, add internal standard to dissolve k, dilute it to the scale, shake it well, and use it as a test solution. In addition, an appropriate amount of the reference product of eugenene, eugenol and eugenol acetate was accurately weighed, and dissolved and quantitatively diluted with internal standard solution to make about 1 mL/l. Omg, 8. 8mg with 1. O m g mixed solution, as a control solution. In addition, 1 0 of the reference solution and the test solution were separately injected into the human gas chromatograph, and the chromatogram was recorded. The peak area was calculated according to the internal standard method.
Last Update：2022-01-01 11:20:00
CLOVE LEAF OIL - Category
Authoritative Data Verified Data
pharmaceutical excipients, fragrances and flavors, etc.
Last Update：2022-01-01 11:20:01
CLOVE LEAF OIL - Storage
Authoritative Data Verified Data
sealed, stored in the cool dark.
Last Update：2022-01-01 11:20:01
CLOVE LEAF OIL - Reference Information
| FEMA | 2323 | CLOVE BUD OIL (EUGENIA SPP.) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | clove (eugeniacalyllathu B.). Clove oil is an essential oil extracted from clove flower buds, which can treat toothache, bronchitis, neuralgia, stomach acid, resist respiratory and urinary tract infections, and reduce discomfort and pain caused by dysentery, improve the weak body and anemia, aphrodisiac (impotent, cold feeling), deworming. Promote blood circulation, treatment of skin ulcers and wound inflammation, treatment of scabies, improve rough skin. |
| extraction method | take G of clove powder, put it in a ML round bottom flask, and add ml of water. The volatile oil extraction device was placed on the reflux extraction 4H, and the volatile oil was collected. To the collected volatile oil, 5ml of a petroleum fan was added and slightly shaken. After standing, the oil and water layers were separated, the water layer was removed, and the oil fan was distilled off at 40 ° C. To obtain pure clove oil with a yield of 0.67%. |
| assay | was determined by the phenolic assay (OT-37). The phenol content in terms of eugenol was thus determined. |
| toxicity | GRAS(FEMA H)A,§ 184.1257,2000). GRAS(FEMA;FDA,§ 184.1257,2000). |
| usage limit | FEMA(mg/kg): meat products 810; Baked goods 1200; Beverages 20-1000; ice flood 33; Sweet cherry 500. |
| Use | spices. It is mainly used for ham, sausage, meat soup, gum, chocolate pudding, cake, pickled food, sauce, sweet and seasoning. Indonesian clove and tobacco mixed into a known "kretek" cigarette. is important for natural flavors and medicines. Widely used in daily chemical products, food, tobacco, alcohol, etc. Commonly used as pain relievers and wind, sterilization and disinfection drugs. Also used for the extraction of eugenol and synthesis of isoeugenol, benzyl isoeugenol and other spices. used in medicine for antiseptic and oral Disinfection, industry is mainly used for the preparation of toothpaste and soap flavor or used as a raw material for the synthesis of vanillin China GB 2760-96 provisions for the allowed use of edible spices. It is mainly used for cooking seasoning, kimchi and cakes. ammonia was assayed. For microscopy. Manufacturing of spices. immunomodulators and anti-inflammatory drugs. |
| method of production | The product consists of a clove tree of the myrtol family (Eugenia cnryozlata or E. Et al. Aromatica) dried unopened flower buds were obtained by steam distillation. The yield was 15%-21%. If distilled with water, the yield is about 10% ~ 15%, and the eugenol content is also lower than the former. It is mainly produced in Zambia and Madagascar. China's Guangdong, Fujian also produced. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2020 mg/kg |
| stimulation data | Skin-rabbit 500 mg/24 h severe |
| flammability hazard characteristics | flammable; Spicy and irritating smoke released from fire scene |
| storage and transportation characteristics | warehouse low temperature, ventilation, dry; Fire protection; Separate storage with oxidant |
| fire extinguishing agent | water, carbon dioxide, dry powder, foam |
Last Update：2024-04-09 21:04:16
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